Computer search for molecular mechanisms of ulcerogenic action of nonsteroidal antiinflammatory drugs

Use of Nonsteroidal Antiinflammatory Drugs

Clinical trial data have prompted questions about the degree to which patients and their physicians should consider an increased risk of cardiovascular or cerebrovascular events when selecting medications for pain relief. Since the 2005 publication of a Science Advisory on the use of nonsteroidal antiinflammatory drugs (NSAIDs) by the American Heart Association,1 several important events have o...

Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.

From the Department of Biology, University of North Dakota, Grand Forks (T.R.); the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, N.C. (J.A.C.); and the Department of Health and Human Services, National Institutes of Health, Bethesda, Md. (J.A.C.). Address reprint requests to Dr. Cidlowski at the Laboratory of Signal Transduction...

Nonsteroidal antiinflammatory drugs for adjunctive tuberculosis treatment.

Tuberculosis continues to cause 1.4 million deaths annually despite effective treatment being available since the 1970s. The standard 4-drug tuberculosis treatment regimen involving isoniazid, rifampicin, pyrazinamide, and ethambutol achieves 90%cure rates in programmatic settings [1]. Mycobacterium tuberculosis bacilli are difficult to eradicate since they exist in a spectrum of replication st...

Colonic side effects of nonsteroidal antiinflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are a widely prescribed group of drugs, known to be responsible for many cases of gastroduodenal ulcers by inhibiting cyclo-oxygenase (1). The incidence of side effects while taking NSAID therapy is high, and has been reported to approach 70% in patients receiving long-term therapy. The most frequent complications are those involving the gastroduod...

Osteoarthritis: simple analgesics versus nonsteroidal antiinflammatory drugs.